Tramadol is an opioid pain medication sold under the brand name Ultram. It is prescribed to treat moderate to moderately severe pain arising due to acute injuries, surgeries, or chronic conditions like arthritis and fibromyalgia.  However, some tramadol risks are known, and thus, doctors don’t usually recommend it for long-term usage. One of the Tramadol risks includes the incidence of serotonin syndrome in patients.

In this post, we’ll discuss the risks associated with taking tramadol and along with some precautions you should take.

Tramadol Risks of Serotonin Syndrome

Let’s come directly to the point. Are you at the risk of serotonin syndrome if you buy tramadol online? The short answer is, unfortunately, yes.

Tramadol acts not only as an opioid but also as a serotonin and norepinephrine reuptake inhibitor. It is a prodrug, with its efficacy and side effects being governed by cytochrome P450 metabolism.

Therefore, serotonin syndrome is one of the uncommon but possible tramadol risks, which is secondary to excessive serotonergic activity.

Other Tramadol Side Effects

If you order tramadol cash on delivery, there are some other side effects you might face. Some common adverse effects include:

• Nausea
• Lightheadedness
• Dizziness
• Vomiting
• Headache
• Drowsiness

However, most of these side effects occur because your body is trying to adapt to the new drug. Hence, these effects disappear automatically in a few days. But if they don’t, be sure to get medical help.

There are some serious tramadol side effects as well. These include:

• Interrupted breathing during sleep (sleep apnea)
• Severe abdominal pain
• Adrenal glands malfunctioning
• Difficulty urinating
• Mental/mood changes
• Fainting
• Seizures
• Irregular heartbeat

If you notice any of these effects, get medical help immediately.

Precautions of Tramadol

Since tramadol is associated with some serious side effects, patients should take appropriate precautions before they buy tramadol USA to USA.
First and foremost, tell your doctor if you are allergic to tramadol, opioids, or SSRIs. Also, inform your doctor if you are suffering from any underlying medical condition or have a history of chronic disease.

You should be extra cautious while taking tramadol if you’re suffering from one of the following conditions:

• Brain disorders like seizures, head injury
• Mental/mood disorders like confusion, anxiety, depression
• Gallbladder disease
• Disease of the pancreas like pancreatitis
• Intestinal problems blockage, diarrhea
• Breathing problems like sleep apnea, asthma, COPD
• Substance use disorder
• Difficulty urinating

In addition, tramadol is also known to react with certain drugs and medications. Tell your doctor if you are taking any prescription or non-prescription drugs or herbal products. Some medications that react with tramadol are:

• MAO inhibitors like isocarboxazid, linezolid
• Drugs that increase serotonin, like antidepressants
• Quinidine
• Azole antifungals
• HIV drugs
• Seizure drugs


Tramadol is a renowned drug widely used to treat moderate to moderately severe pain. But since it acts like an opioid, it can cause adverse effects, some of which could be severe. One of these tramadol risks includes serotonin syndrome. Other effects like nausea and vomiting are also common. Therefore, it’s crucial to consult your doctor before starting tramadol treatment.

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